Yes – WooCommerce powers six-figure catalogues, but at 100,000 products engineering is everything.
Everything that matters at 50,000 products matters more here. You need serious database tuning, a dedicated search solution (Elasticsearch or a purpose-built fast search plugin, since default search won’t cope), robust multi-layer caching, and hosting sized specifically for the load. Admin operations (bulk edits, imports) also need care so they don’t time out.
At the very top end, some large stores move the storefront to a headless architecture for speed while keeping WooCommerce as the backend – though most stores never need to go that far.
The consistent theme: a 100,000-product store that’s slow is slow because of configuration, not catalogue size. Built properly, it flies. More: 50,000 products · is headless worth it?