For most merchants who want to own their store rather than rent it, yes.
WooCommerce is worth it when you value what it gives you: full ownership of your store and data, no per-sale platform fees, unlimited customisation, and no ceiling on how far you can scale. The price of those things is that you invest in running it well – good hosting, performance and UX.
It’s not worth it if you want the absolute simplest, hands-off store, have a very simple catalogue, and genuinely don’t mind renting your storefront and paying transaction fees. For that, a hosted platform is less work.
Where WooCommerce clearly pays off is when it’s engineered properly rather than left on defaults. Our clients have seen net sales up 582% and revenue up 83% in nine weeks – on native WooCommerce, without replatforming. The platform is worth it; getting the configuration right is what makes it pay.
More: the disadvantages · vs Shopify